The Dihydrouridine landscape from tRNA to mRNA: a perspective on synthesis, structural impact and function
The universal dihydrouridine (D) epitranscriptomic DR. FORMULATED ORG KIDS BERRY CHERRY mark results from a reduction of uridine by the Dus family of NADPH-dependent reductases and is typically found within the eponym D-loop of tRNAs.Despite its apparent simplicity, D is structurally unique, with the potential to deeply affect the RNA backbone and