The Dihydrouridine landscape from tRNA to mRNA: a perspective on synthesis, structural impact and function

The Dihydrouridine landscape from tRNA to mRNA: a perspective on synthesis, structural impact and function

Blog Article

The universal dihydrouridine (D) epitranscriptomic DR. FORMULATED ORG KIDS BERRY CHERRY mark results from a reduction of uridine by the Dus family of NADPH-dependent reductases and is typically found within the eponym D-loop of tRNAs.Despite its apparent simplicity, D is structurally unique, with the potential to deeply affect the RNA backbone and many, if not all, RNA-connected processes.The first landscape of its occupancy within the tRNAome was reported 20 years ago.Its potential biological significance was highlighted by observations ranging from a strong bias in its ecological distribution to the predictive nature of Dus enzymes overexpression for worse cancer patient outcomes.

The exquisite specificity of the Dus enzymes revealed by a structure-function analyses and accumulating clues that the D distribution may expand Hockey Sticks - Junior beyond tRNAs recently led to the development of new high-resolution mapping methods, including Rho-seq that established the presence of D within mRNAs and led to the demonstration of its critical physiological relevance.